TLR4 Mouse Monoclonal Antibody [Clone ID: HTA125]
CAT#: SM1677B
TLR4 mouse monoclonal antibody, clone HTA125, Biotin
Conjugation: Unconjugated FITC
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Specifications
Product Data | |
Clone Name | HTA125 |
Applications | FC |
Recommended Dilution | Flow cytometry. |
Reactivities | Canine, Guinea Pig, Human, Monkey, Porcine |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Ba/F3 cell line expressing TLR4 (CD284). Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line. |
Specificity | This antibody recognises the Toll like receptor 4 (TLR4) cell surface antigen. This antibody has been demonstrated to block activation of monocytes with LPS. We recommend the use of SM1677LE for this purpose. |
Formulation | PBS containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer. Label: Biotin State: Liquid purified IgG fraction. |
Concentration | lot specific |
Purification | Affinity chromatography on Protein G |
Conjugation | Biotin |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens toll-like receptor 4 (TLR4), transcript variant 1 |
Database Link | |
Background | TLR4, also known as CD284, has been demonstrated to act as a receptor for LPS on human monocytes and macrophages. TLR4 signalling of LPS stimulation requires the presence of the MD-2 molecule. TLR4 is weakly expressed by resting cells, but is upregulated following stimulation with LPS. |
Synonyms | Toll-like receptor 4 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Pathogenic Escherichia coli infection, Toll-like receptor signaling pathway |
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